Enduring memories Wheels (Accessories) of sensory cues associated with drug intake drive addiction.It is well known that stressful experiences increase addiction vulnerability.However, it is not clear how repeated stress promotes learning of cue-drug associations, as repeated stress generally impairs learning and memory processes unrelated to stres
LINC00612/miR-31-5p/Notch1 Axis Regulates Apoptosis, Inflammation, and Oxidative Stress in Human Pulmonary Microvascular Endothelial Cells Induced by Cigarette Smoke Extract
Jun Luo,1,* Li Li,2,* Die Hu,2 Xian Zhang1 1Department of Laboratory Medicine, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Dujiangyan People’s Hospital, Dujiangyan 611830, Sichuan, People’s Republic of China*These authors contri
A New Method for Horizontal Axis Wind Turbine (HAWT) Blade Optimization
Iran has a great potential for wind energy.This paper introduces Incense optimization of 7 wind turbine blades for small and medium scales in a determined wind condition of Zabol site, Iran, where the average wind speed is considered 7 m /s.Considered wind turbines are 3 bladed and radius of 7 case study turbine blades are 4.5 m, 6.5 m, 8 m, 9 m, 1
Rab3D is critical for secretory granule maturation in PC12 cells.
Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature Wheels (Accessories) secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.This maturation process is characterized by acidification-dependent processing of cargo proteins, condensation of the
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection
The innate immune response to viral pathogens is critical in order to mobilize protective immunity.Cells of the innate immune system detect viral infection largely through germline-encoded pattern recognition receptors (PRRs) present either on the cell surface or within distinct intracellular compartments.These include the Toll-like receptors (TLRs