Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and copyright place conditioning

Enduring memories Wheels (Accessories) of sensory cues associated with drug intake drive addiction.It is well known that stressful experiences increase addiction vulnerability.However, it is not clear how repeated stress promotes learning of cue-drug associations, as repeated stress generally impairs learning and memory processes unrelated to stres

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LINC00612/miR-31-5p/Notch1 Axis Regulates Apoptosis, Inflammation, and Oxidative Stress in Human Pulmonary Microvascular Endothelial Cells Induced by Cigarette Smoke Extract

Jun Luo,1,* Li Li,2,* Die Hu,2 Xian Zhang1 1Department of Laboratory Medicine, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Dujiangyan People’s Hospital, Dujiangyan 611830, Sichuan, People’s Republic of China*These authors contri

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Rab3D is critical for secretory granule maturation in PC12 cells.

Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature Wheels (Accessories) secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.This maturation process is characterized by acidification-dependent processing of cargo proteins, condensation of the

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